Bubble Boy (2001)

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Overview: Jimmy is a young man who was born without an immune system and has lived his life within a plastic bubble in his bedroom... who pines for the sweet caresses of girl-next-door Chloe. But when Chloe decides to marry her high school boyfriend, Jimmy – bubble suit and all – treks cross-country to stop her.

Starring: Jake Gyllenhaal, Swoosie Kurtz, Marley Shelton, Danny Trejo